Adept Adhesion Reduction Solution (4% Icodextrin)
Adept Adhesion Reduction Solution (4% Icodextrin) has been proven to reduce post-surgical adhesions in patients undergoing gynecological laparoscopic adhesiolysis. Its unique properties offer a simple solution resulting in better outcomes in the OR and for the patient overall.
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Overview
The Impact of Adhesions
#1 Cause of Secondary Infertility in Women
Adhesions are the number one cause of secondary infertility in women.1
34.5% of Women Readmitted into Hospital for Further Surgery
Following initial gynecologic surgery, up to one in three patients were readmitted for a problem potentially related to adhesions or for further surgery potentially complicated by adhesions over a ten-year period.2
Lysis of Adhesions at Reoperative Surgery
Is associated with inadvertent organ injury, prolonged operative time, an increased risk of post-operative complications, and higher costs.3
The Only FDA-Approved Fluid-Based Solution for Gynecological Adhesion Reduction 4
Adept Adhesion Reduction Solution (4% Icodextrin) is a non-viscous, colorless liquid used for intraperitoneal administration to reduce adhesions in gynecological laparoscopic adhesiolysis. The solution contains 4% icodextrin and does not impair viewing or the handling of tissue.4
Features
A Simple and Effective Solution
- Direct and Fast-Acting Application: As a liquid, Adept is administered directly and rapidly to the site through a laparoscopic port during surgery5
- Broad Coverage and Optimized Resorption: Ingredient icodextrin slows the resorption time, whereas regular fluids would be resorbed much faster6
Proven Clinical Success with the PAMELA Study
Double-blind randomized controlled trial comparing Adept (n=203) and Lactated Ringer's Solution (n=199) during laparoscopic gynecological surgery8
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Ordering and Support Information for Adept Adhesion Reduction Solution (4% Icodextrin)
Get additional ordering, customer, technical, and medical support information for Adept Adhesion Reduction Solution (4% Icodextrin) by contacting Baxter using the links below.
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Adept Adhesion Reduction Solution (4% Icodextrin) Indications and Important Risk Information
ADEPT Adhesion Reduction Solution (4% Icodextrin) Indications
Adept Adhesion Reduction Solution is indicated for use intraperitoneally as an adjunct to good surgical technique for the reduction of post-surgical adhesions in patients undergoing gynecological laparoscopic adhesiolysis.
ADEPT Important Risk Information
Adept Solution is for direct intraperitoneal administration only. NOT for intravenous (IV) administration.
Adept is contraindicated in patients with known or suspected allergy to cornstarch based polymers e.g. icodextrin, or with maltose or isomaltose intolerance, or with glycogen storage disease.
Adept is contraindicated in laparotomy, in cases involving bowel resection or repair, or appendectomy and in surgical cases with frank abdomino-pelvic infection.
There have been rare reports of sterile peritonitis following the use of icodextrin.
Leakage of Adept from port sites may lead to wound healing complications; meticulous fascial closure may reduce leakage through laparoscopic port sites post-operatively.
There have been rare reports of hypersensitivity reactions, pulmonary edema, pulmonary effusion and arrhythmia.
Anaphylaxis has been reported in a few patients.
Maltose metabolites of icodextrin may interfere with blood glucose measurement in diabetic patients who use rapid blood glucose systems that are not glucose specific.
In the pivotal study, the most frequently occurring treatment related adverse events between surgeries were post procedural leaking from port sites, labial, vulvar or vaginal swelling and abdominal distention.
Rx Only: For safe and proper use of this device, please refer to full Instructions For Use.
Disclaimers
Rx only. For safe and proper use of product mentioned herein, please refer to the Instructions for Use or Operator Manual.
Baxter, Adept, Cosseal, Floseal and Tisseel are trademarks of Baxter International Inc. or its subsidiaries. Any other trademarks, product names or brand images are the property of their respective owners.
References
- DeWilde RL, et al., Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position, Gynecol Surg, 4:161-168, 2007.
- Lower AM, Hawthorn RJ, et al. The impact of adhesions on hospital readmissions over ten years after 8849 open gynaecological operations: an assessment from the Surgical and Clinical Adhesions Research Study, British Journal of Obstetrics & Gynaecology, July 2000, Vol. 107., pp. 855-862.
- Krielen, et al. World Journal of Emergency Surgery, 14, Article number 41, 2019.
- Brown, et al., ADEPT® [4% icodextrin] solution reduces adhesions after laparoscopic surgery for adhesiolysis; a double-blind, randomized, controlled study, Ferility and Sterility®2007;88[5]:1413-1426.
- Adept Adhesion Reduction Solution [4% icodextrin], Instructions for Use, 2006.
- diZerega GS, et al., A randomized controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgery. Human Reproduction, Vol. 17, No. 4 pp. 1-31-1038, 2002.
- Verguts, J et al; Clearance Rates of Ringer's Lactate and Adept® and the Effect of Full Conditioning: A Randomized Controlled Trial. Journal of Gynecological Surgery. 2015;31(3):139.
- Brown, et al., ADEPT® [4% icodextrin] solution reduces adhesions after laparoscopic surgery for adhesiolysis: a double-blind, randomized, controlled study, Fertility and Sterility®2007;88[5]:1413-1426.