Altapore Bioactive Bone Graft Substitute
Altapore bioactive bone graft substitute enables surgeons to think creatively while providing the enhanced porosity and adaptability that today’s challenging orthopedic surgeries require.
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Overview
Introducing Altapore MIS System
The Altapore MIS System is designed to assist surgeons who want a simple, ready-to-use bone grafting system for open and minimally invasive procedures.
The system combines extended reach, controlled delivery and precise bone graft placement in a specially designed applicator with Altapore Bioactive Bone Graft Substitute.
Enhanced Bone Growth
With enhanced micro and macro porosity and silicon content shown to be optimal for bone formation, Altapore is designed to promote early vascularization, increase cellular activity and enhance bone growth as demonstrated in pre-clinical and in-vitro studies. *1,2,3
*Preclinical data. Results may not correlate to performance in humans.
Features
Clinically Proven Fusion Rates
In a prospective, open-label, non-randomized, multicenter clinical study including 102 patients, Altapore achieved successful fusion in 86.3% of patients within 12 months following posterolateral fusion (PLF) surgery with instrumentation.4
Additional Product Benefits
Enhanced Performance
Altapore achieves fusion rates on par with autograft—the gold standard in bone fusion.*4-6
*The fusion rate of 86.3% at month 12 with Altapore Bioactive Bone Graft is an improvement in rates of 52 -80%, observed with traditional autologous iliac crest and allograft material in PLF surgery
Versatility and Ease of Use
The precise handling characteristics of Altapore allow the product to be molded into multiple shapes to adapt to various surgical needs when using as standalone, with autograft, or bone marrow aspirate.1
Enhanced Porosity
The interconnected and open porous structure of the silicate-substituted calcium phosphate phase of Altapore is similar to human cancellous bone and is designed to promote enhanced bone growth.2
Order & Support
Learn More About Altapore Bioactive Bone Graft Substitute
Ordering and Support Information for Altapore Bioactive Bone Graft Substitute
Get additional ordering, customer, technical, and medical support information for Altapore Bioactive Bone Graft Substitute by contacting Baxter using the links below.
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Altapore Bioactive Bone Graft Substitute Indications and Important Risk Information
ALTAPORE Bioactive Bone Graft Shape Indications
Altapore Bioactive Bone Graft Shape is an implant intended to fill bony voids or gaps of the skeletal system (i.e., extremities, posterolateral spine and pelvis). Altapore Bioactive Bone Graft Shape can be used by itself, or with autograft as a bone graft extender in posterolateral spinal fusion procedures.
These osseous defects may be surgically created or the result of traumatic injury to the bone and are not intrinsic to the stability of the bony structure.
Altapore Bioactive Bone Graft Shape resorbs and is replaced with bone during the healing process.
Important Risk Information
Altapore Bioactive Bone Graft is contraindicated where the device is intended as structural/load-bearing support in the skeletal system. Altapore Bioactive Bone Graft has not been cleared for use in vertebroplasty. Attempts should not be made to modify the size of the granules or to change their shape. It is important to maximize contact between existing bone and the implant to ensure proper bone regeneration.
The effect of mixing Altapore Bioactive Bone Graft with substances other than bone marrow aspirate or autologous bone is unknown.
Disclaimers
Rx only. For safe and proper use of product mentioned herein, please refer to the Instructions for Use or Operator Manual.
Baxter, Altapore, Cosseal, Floseal and Tisseel are trademarks of Baxter International Inc. or its subsidiaries. Any other trademarks, product names or brand images are the property of their respective owners.
References
- Altapore Shape Bioactive Bone Graft Instructions for Use.
- Hing KA, Revell PA, Smith N, Buckland T. Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds. Biomaterials. 2006 Oct;27(29):5014-26.
- Campion CR, Chandler C, Buckland T, Hing K. Increasing strut porosity in silicate-substituted calcium-phosphate bone graft substitutes enhances osteogenesis. J Biomed Mater Res B Appl Biomater. 2011 May; 97(2):245-54.
- Bolger Ciaran and Jones, D. (2019, 7). Evaluation of an increased strut porosity silicate-substituted calcium phosphate, SiCaP EP, as a synthetic bone graft substitute in spinal fusion surgery: a prospective, open-label study. European Spine Journal, 28(7), 1733-1742.
- Hsu WK, Nickoli MS, Wang JC, Lieberman JR, An HS, Yoon ST, Youssef JA, Brodke DS, McCullough CM. Improving the clinical evidence of bone graft substitute technology in lumbar spine surgery. Global Spine J. 2012 Dec;2(4):239-48.
- An H S, Lynch K, Toth J. Prospective comparison of autograft vs. allograft for adult posterolateral lumbar spine fusion: differences among freeze-dried, frozen, and mixed grafts. J Spinal Disord. 1995;8:131–135.